LITTLE KNOWN FACTS ABOUT ALPRAZOLAM.

Metabolism Alprazolam is extensively metabolized in individuals, primarily by cytochrome P450 3A4 (CYP3A4), to 2 key active metabolites while in the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation levels of the two active metabolites are below 4% from the guardian. The noted relative potencies in benzodiazepine receptor